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Principal Scientist - API Process Development Job Opening In Dublin – Now Hiring Cpl

Principal Scientist API Process Development

    Ireland Jobs Expertini Expertini › Ireland › Jobs › Dublin › Life Scientists › Principal Scientist Api Process Development

Job description

Cpl in partnership with SK pharmteco are looking to hire a permanent Principal Scientist for API Process Development onsite in the Swords Campus

ABOUT US?

SK pharmteco, part of SK Inc, is a global Contract Development and Manufacturing organisation (CDMO) with state-of the-art small molecule manufacturing facilities in Korea, US, and Ireland.

The SK Small Molecule Europe facility located in Swords, Co Dublin, Ireland has led the way in the development, scale-up and commercial manufacture of Active Pharmaceutical Ingredients (APIs) and Chemical Intermediates for over 60 years.

With a talented workforce, exceptional technical capabilities and facilities we make some of the world’s most important medicines.

Further information on SK pharmteco can be found at

Current Need:

SK pharmteco Ireland are seeking to recruit a highly experienced Principal Scientist to lead a team in the process R&D group on a permanent contract.

We are seeking a highly skilled and motivated Principal Scientist / Chemist to join our Process Development team within a dynamic CDMO environment.

The successful candidate will lead the development, optimization, and scale-up of robust, safe, and cost-effective chemical processes for the manufacture of Active Pharmaceutical Ingredients (APIs) and intermediates, from clinical through commercial stages.

This is a senior-level role that demands both technical expertise and leadership capabilities, with opportunities to mentor junior scientists and interface directly with clients and cross-functional teams.

As a Principal Scientist in API Process Development at our SK Pharmteco site you will play a key leadership role in delivering high-quality, innovative solutions for our global clients.

This role combines deep expertise in API process development with a passion for adopting cutting-edge technologies to drive efficiency, quality, and scalability across diverse development programs.

You will be responsible for leading the design, development, and scale-up of chemical processes for small-molecule APIs, while evaluating and implementing new manufacturing technologies such as continuous flow processing, process analytical technologies (PAT), and digital process optimization tools.

You will act as both a technical expert and a client-facing scientific leader, helping ensure successful development, technology transfer, and GMP manufacturing within tight timelines and regulatory frameworks.

Primary Responsibilities:

  • Lead end-to-end development of API processes from route scouting through scale-up and GMP manufacturing for client programs across clinical and commercial phases.
  • Collaborate with clients and internal stakeholders to define development strategies, technology selection, timelines, and deliverables.
  • Evaluate and implement innovative process technologies to improve yield, robustness, scalability, sustainability, or cost-efficiency, including the following non exhaustive list:Continuous flow chemistryCrystallisation DevelopmentAdvanced automation and real-time data analyticsPAT tools and real-time release testingGreen chemistry principles and solvent reduction
  • Contribution to successful technology transfer into the site from clients or partner organizations, and from development to manufacturing.
  • Serve as the scientific lead in troubleshooting process issues during familiarization, optimisation and scale up, ensuring rapid and compliant resolution.
  • Perform risk assessments, identify and mitigate potential scale-up or safety issues (e.g., thermal hazards, exothermic reactions).
  • Develop and implement Design of Experiments (DoE) to optimize critical process parameters.
  • Collaborate closely with internal cross-functional teams including Analytical, Quality Assurance, Tech.

    transfer, Manufacturing, Engineering, Supply chain and SHE.

  • Author and review technical documentation, including process development reports, risk assessments, and CMC regulatory submissions.
  • Stay current with emerging trends and technologies in chemical process development and apply them strategically to enhance client offerings.

    • ·Mentor and develop scientists within PR&D and contribute to a culture of innovation and continuous improvement.

    Qualifications:

    Education:

  • Ph.D. in Organic Chemistry, Chemical Engineering, or a related discipline.
  • M.Sc. with significant industry experience will also be considered.

    • Experience:

  • 8–12+ years of relevant experience in pharmaceutical API process development, preferably in a CDMO or fast-paced multi-client environment.
  • Proven track record in process scale-up, technology transfer and GMP manufacturing.
  • Strong understanding of CDMO operations, client engagement, and regulatory expectations (e.g., IND, IMPD, NDA, MAA submissions).
  • Strong technical experience in new technologies (flow chemistry, PAT, automation, etc.

    and leadership in implementing new technology projects.

  • >5 years’ experience leading teams in the delivery of complex process development projects.

    • Key Skills & Attributes:

  • Strategic scientific and technical leadership across diverse projects and molecules.
  • Effective communicator with a track record of building strong partnerships with internal stakeholders and external clients.

  • Experience managing client expectations and highly skilled at translating complex technical progress into concise updates.

  • Deep knowledge of synthetic organic chemistry or chemical engineering principles applied to scalable API manufacturing.
  • Experience applying QbD and risk assessment tools as part of process development to meet regulatory expectations.
  • A strong collaborative mindset with a willingness to take ownership and ability to thrive in a dynamic, client-driven environment.

    • Other Benefits include:

    ·Excellent opportunities for career enhancement and personal development

    ·Competitive base salary

    ·Annual bonus linked to business results

    ·A well-established further education program.

    ·Pension scheme

    ·Private Healthcare

    SK pharmteco SM Europe is an equal opportunity employer

    Required Skill Profession

    Life Scientists


    • Job Details

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